Depending on the setup of your computer and specifically Windows 10 updates you have on your computer, the Leica USB driver may conflict with Windows Mobile Device Center.
Ideally, users to download the appropiate GS/CS/TS driver (as found in Leica MyWorld) and install accordingly:
If Windows Mobile device does NOT launch automatically on connection to a powered GS/CS/TS device, the following is a link to download a quickguide to potentially correct an issue on Windows 10 updates
This will download a pdf file and zip file to correct issue
Windows Mobile Device Centre Issue